I performed my PhD thesis, which you can find here, in Miguel Torres’s lab at the Centro Nacional de Investigaciones Cardiovasculares in Madrid, Spain.

In it I analyzed the binding profile of a developmentally critical set of Transcription Factors, proteins that can bind DNA and regulate the expression of other genes as well as their own. I studied their effect on transcription and elucidated their in vivo combinatorial binding. I found out that their binding sites and recognized DNA patterns are actually a lot more restricted in a real live system that they appear to be from in vitro binding experiments.

Papers and reviews

Marcos, S., Gonzalez-Lazaro, M., Beccari, L., et al (2015). “Meis1 coordinates a network of genes implicated in eye development and microphthalmia” Development 142.17, pp. 3009–3020

Longobardi, E., Penkov, D., Mateos, D., et al (2014). “Biochemistry of the tale transcription factors PREP, MEIS, and PBX in vertebrates” Dev Dyn 243.1, pp. 59–75

Penkov, D., Mateos San Martin D., Fernandez-Diaz L., et al (2013). “Analysis of the DNA-Binding Profile and Function of TALE Homeoproteins Reveals Their Specialization and Specific Interactions with Hox Genes/Proteins” Cell Reports 3.4, pp. 1321-1333

Bass, B. P., Tanner, E., Mateos San Martin, D., et al (2009). “Cell-autonomous requirement for DNaseII in nonapoptotic cell death.” Cell Death Differ 16.10, pp. 1362–1371

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