I performed my PhD thesis, which you can find here, in Miguel Torres’s lab at the Centro Nacional de Investigaciones Cardiovasculares in Madrid, Spain.
In it I analyzed the binding profile of a developmentally critical set of Transcription Factors, proteins that can bind DNA and regulate the expression of other genes as well as their own. I studied their effect on transcription and elucidated their in vivo combinatorial binding. I found out that their binding sites and recognized DNA patterns are actually a lot more restricted in a real live system that they appear to be from in vitro binding experiments.
Papers and reviews
Penkov, D., Mateos San Martin D., Fernandez-Diaz L., et al (2013). “Analysis of the DNA-Binding Profile and Function of TALE Homeoproteins Reveals Their Specialization and Specific Interactions with Hox Genes/Proteins” Cell Reports 3.4, pp. 1321-1333